![]() ![]() Nanotechnology involves the precise manipulation of atoms and molecules to manufacture micro-scale products. These structures can form transiently at certain points of the cell cycle, but their function is not yet known and is the object of study. In this new study, the scientists analysed the behaviour of certain sequences in environments with differing degrees of acidity (different pH). Published in The Journal of the American Chemical Society (JACS), the study is the continuation of previously published work, which described the behaviour of some peculiar i-motifs that are stable in neutral environments. This is the first study to report the conformational change of i-DNA and it reveals the plasticity of these structures. In addition, this transition has been described with molecular dynamics studies, which have demonstrated that the unfolding of the i-motif is not necessary for changes in its conformation. Carlos González, from the Rocasolano Physical Chemistry Institute (CSIC), have characterised two distinct conformations of a pH-dependent DNA molecule. Nuria Escaja, from the Department of Inorganic and Organic Chemistry of the University of Barcelona, and Dr. Modesto Orozco, in collaboration with Dr. Using Nuclear Magnetic Resonance (NMR), researchers from IRB Barcelona led by Dr. This structure can occur transiently at certain points of the cell cycle, but its function is unknown. However, in some cases, such as the i-motif, also known as i-DNA, the base pair is formed by a C with another C. In the double helix, the base pairs are formed by G with C and A with T. DNA has four nitrogenous bases, namely cytosine (C), guanine (G), adenine (A), and thymine (T), which are located in the form of base pairs at the centre of the molecule. This biomolecule is highly flexible and therefore presents a wide variety of structures. In 1953, the main structure of DNA was discovered as a double helix. ![]()
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